PRF: Platelet Rich Fibrin
Rockwall & Paris, Texas
Platelet-rich fibrin (PRF) is an autologous platelet concentrate that is playing an increasingly important role in periodontal regeneration, implant dentistry, oral and maxillofacial surgery, and post-extraction site preservation. Unlike other biomedical modifiers, which are prepared with artificial additives or anticoagulants, PRF has autologous fibrin membranes and plugs that have a high concentration of white cells and platelets, which when placed at a surgical site, can release growth factors for up to two weeks, resulting in an accelerated healing process. PRF has been used in hospitals for years, and is now used with greater frequency to facilitate healing and regeneration. PRF can be used in combination therapies with other biomaterials, in additive or stand-alone therapies, as an injectable or liquid form, and as a membrane.
Once prepared, the PRF can be used to facilitate the healing process following various procedures, including:
- Ridge Augmentation/Bone Grafting for Implants
- Direct sinus lifts
- Multiple implants
- Nonsurgical Scaling and Root Planning with the Periodontal Endoscope
- Bone Repair
- Removal of growths and cysts
- Gingival grafting
- Fistula repair
- Onlay and inlay grafts
Platelet Rich Fibrin
Treatment & Process
Before performing the procedure, we will need to determine if you are a viable candidate for PRF Treatment. Although most patients are, individuals with blood clotting disorders will not be good candidates. First, we will collect a sample of your blood, place the sample in glass tubes, and place these tubes in a centrifuge for approximately twelve minutes, which will isolate the platelets in your blood and create a concentrate or a “plug”. Once this centrifuge process is complete, the tubes are placed in a sterile tube holder and the plug is extracted from the tube. This process of centrifugation separates the blood sample into blood cells that gather at the bottom of the tube, a strongly polymerized fibrin in the middle, and acellular plasma at the top. The plug forms a fibrin matrix which concentrates nearly all the growth factors and platelets of the blood harvest that results in unique mechanical properties that will rapidly accelerate the healing process.
To prepare a PRF membrane, the plug is removed from the tube and scissors are used to separate the red blood cell fragment and the fibrin plug or clot. Once the PRF membranes are ready, they will remain useable for several hours following preparation, provided they are conserved in physiologic conditions and prepared correctly. Once prepared, you will undergo the procedure you have been scheduled for and the platelet-rich-fibrin membrane will be applied towards the end of the procedure. You should not experience have any discomfort when the PRF membrane is placed since local anesthetic has already been administered. For example, in the case of a ridge preservation procedure for a dental implant, PRF will be placed over the bone grafted area after which the socket is closed and the healing process can begin. Within a few months, the site will have healed bone in the area and will be ready for implant placement.
Aftercare Instructions
Following any type of periodontal procedure, your body undergoes a recovery process as it begins to restore blood vessels, tissue, and bone around where the surgery occurred. Although PRF will help your body in this healing process, it is still important that you follow aftercare instructions provided to you following your procedure. It is also important to understand that although research supports the efficacy of PRF in facilitating the healing process, everyone heals at a different rate. Factors such as your overall health, the type of procedure you have performed, and your age will all play a role in your rate of recovery.
Platelet Rich Fibrin
Treatment Benefits
In addition to helping facilitate tissue regeneration at a much faster rate, PRF also has the following benefits:
- No anticoagulants
- Fibrin polymerization is not affected
- Free of animal products that could affect immune system activation and coagulation process
- Growth factors are protected from proteolysis by natural fibrin network
- More efficient cell migration
- Contains leukocytes, monocytes, and other white cells
- Reduced risk of infection
- Improved strength of bone integration for dental implants
Platelet Rich Fibrin
Costs associated
In addition to helping facilitate tissue regeneration at a much faster rate, PRF also has the following benefits:
- No anticoagulants
- Fibrin polymerization is not affected
- Free of animal products that could affect immune system activation and coagulation process
- Growth factors are protected from proteolysis by natural fibrin network
- More efficient cell migration
- Contains leukocytes, monocytes, and other white cells
- Reduced risk of infection
- Improved strength of bone integration for dental implants